Ac-DEVD-CMK
CAS No. : 285570-60-7
(Synonyms: Caspase-3 Inhibitor III)
| Size | Price | Stock |
|---|---|---|
| 1mg | $100 | In-stock |
| 5mg | $400 | In-stock |
| 10mg | $640 | In-stock |
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| Cat. No. : | HY-P0034 |
| M.Wt: | 550.94 |
| Formula: | C21H31ClN4O11 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Ac-DEVD-CMK (Caspase-3 Inhibitor III) is a selective and irreversible caspase-3 inhibitor. Ac-DEVD-CMK significantly inhibits apoptosis induced by high levels of glucose or
Ac-DEVD-CMK inhibits (10 μM; 36 h) inhibits citrate (10 mM)-induced p21 cleavage and G2/M accumulation in human pharyngeal squamous carcinoma FaDu and Detroit 562 cell lines[4].
In Vivo:Ac-DEVD-CMK (Caspase-3 Inhibitor III; 25 mg/kg; IP; single dose; 3 hours post-APAP) significantly attenuates Acetaminophen (APAP; HY-66005)-induced liver injury (AILI)[5].
Ac-DEVD-CMK (25 mg/kg; ip; single dose) significantly attenuates APAP-induced liver injury (AILI) in susceptible Sdc1−/− mice[6].
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