Theaflavin-3'-gallate

Theaflavin-3'-gallate is a monomer of theaflavins found in black tea, which has anti-UVB damage activity and inhibits cell apoptosis and necroptosis. Theaflavin-3'-gallate acts as a pro-oxidant and induces oxidative stress in cancer cells, inhibiting xanthine oxidase (OX), with an IC₅₀ of 7.6 μM^[1][2][3]. IC50 & Target:xanthine oxidase (OX) In Vitro:Theaflavin-3'-gallate (0-500 μM, 24 h) has a toxic effect on HF-1, HSC-2, and CAL27 cells^[1].
Theaflavin-3'-gallate (0-250 μM, 3 h) generates a high amount of peroxide at pH 7.4, and reduces the GSH levels in HF-1 and CAL27 cells^[1].
Theaflavin-3'-gallate is the most effective exogenous H₂O₂ scavenger, showing superoxide scavenging activity in HL-60 cells with an IC₅₀ of 15.6 μM^[2].
Theaflavin-3'-gallate (0.1-40 μM, 6 h) has a protective effect against UV-induced damage in HaCaT cells, with an EC₅₀ of 0.483 μM^[3].
Theaflavin-3'-gallate (5-40 μM, 6 h) protects against apoptosis and necrosis induced by UVB in HaCaT cells, inhibiting oxidative stress and preserving mitochondrial membrane potential^[3].
Theaflavin-3'-gallate (5-40 μM, 6 h) downregulates the NF-κB inflammatory pathway in UV-irradiated HaCaT cells, inhibits the formation of cytotoxic aggregates, and protects the structure of biomacromolecules^[3].