S-Bioallethrin


CAS No. : 28434-00-6

(Synonyms: D-Trans-Allethrin; Esbiol)

28434-00-6
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Cat. No. : HY-122376
M.Wt: 302.41
Formula: C19H26O3
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 28434-00-6 :

S-Bioallethrin (D-Trans-Allethrin) is a pyrethroid insecticide. S-Bioallethrin disrupts nerve function by modifying the gating kinetics of transitions between the conducting and nonconducting states of voltage-gated sodium channels. S-Bioallethrin also causes inhibition of lymphocyte proliferation and induces histamine release from human basophils[1][2][3][4]. In Vitro:S-Bioallethrin (100 μM, 4 ms) enhances and prolongs the sodium tail current measured upon membrane repolarization, showing modification of Nav1.6Q3 in vitro[1].
S-Bioallethrin (0-26 μM,0-72 h) causes inhibition of Phytohemagglutinin (PHA) (HY-N7038)-stimulated proliferation in lymphocytes[2].
S-Bioallethrin (6.5 μM,4-72 h) reduces IL-4 secretion and increases IFN-y release with time in lymphocytes[2].
In Vivo:S-Bioallethrin (1 to 4 mg/kg, i.v., a single dose for 80 min) produces fine tremor and reflex hyperexcitability in conscious rats[4].

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