XAV-939
CAS No. : 284028-89-3
| Size | Price | Stock |
|---|---|---|
| 5mg | $60 | In-stock |
| 10mg | $72 | In-stock |
| 25mg | $144 | In-stock |
| 50mg | $216 | In-stock |
| 100mg | $336 | In-stock |
| 200mg | $600 | In-stock |
| 500mg | $1000 | In-stock |
| 1g | $1400 | In-stock |
| 5 g | Get quote | |
| 10 g | Get quote | |
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| Cat. No. : | HY-15147 |
| M.Wt: | 312.31 |
| Formula: | C14H11F3N2OS |
| Purity: | >98 % |
| Solubility: | DMSO : 15.62 mg/mL (ultrasonic;warming;heat to 60°C) |
XAV-939 is a Tankyrase inhibitor. XAV-939 has inhibitory activity for TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively. XAV-939 also is an enhancer of osteoblastic differentiation of hMSCs. XAV-939 can be used for the research of conditions associated with activated Wnt signaling, such as cancer, fibrotic diseases and conditions associated with low bone formation[1][2][3].
IC50 & Target:IC50: 5 nM (TNKS1), 2 nM (TNKS2)[1]
In Vitro: XAV-939 has activity against TNKS1 and TNKS2 with IC50 values of 5 nM and 2 nM, respectively[1].
XAV-939 (0.3-30 μM; 3 or 10 days) enhances osteoblast differentiation of hBMSCs[2].
XAV-939 (3 μM) promotes osteoblast differentiation of hMSCs via accumulation of SH3BP2[2].
XAV-939 (3 μM; 10 days) upregulates the expression of OPG and downregulates the expression of RANKL in hBMSCs during osteoblast differentiation[2].
XAV-939 suppresses Wnt/β-catenin signaling and promotes SFRP3 and SFRP4 expression[3].
In Vivo: XAV-939 rescues mechanical stress-induced cartilage degeneration in vivo[3].
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