Aloin B
CAS No. : 28371-16-6
(Synonyms: Isobarbaloin)
| Size | Price | Stock |
|---|---|---|
| 5mg | $65 | In-stock |
| 10mg | $104 | In-stock |
| 25mg | $208 | In-stock |
| 50mg | $333 | In-stock |
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| Cat. No. : | HY-N0886 |
| M.Wt: | 418.39 |
| Formula: | C21H22O9 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Aloin B (Isobarbaloin) is an orally active SARS-CoV-2 papain-like protease (PLpro) inhibitor with an IC50 of 16.08 μM (hydrolytic activity) and 17.51 μM (deubiquitinase activity). Aloin B is metabolized by rat intestinal flora into aloe-emodin-9-anthrone to exert laxative effects. Aloin B inhibits TPA (HY-18739)-induced ear edema, putrescine elevation, and tumor promotion in mouse skin. Aloin B can be used in research related to anti-inflammation, tumor promotion inhibition, coronavirus disease 2019 (COVID-19) and constipation[1][2][3]. In Vivo:Aloin B (19.2-31.1 mg/kg; p.o.; single administration) exerts a laxative effect in Wistar rats, with an oral ED50 of 19.2 mg/kg[1].
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