Ethoxysanguinarine
CAS No. : 28342-31-6
| Size | Price | Stock |
|---|---|---|
| 1mg | $65 | In-stock |
| 5mg | $160 | In-stock |
| 10mg | $260 | In-stock |
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| Cat. No. : | HY-N4317 |
| M.Wt: | 377.39 |
| Formula: | C22H19NO5 |
| Purity: | >98 % |
| Solubility: | DMSO : 60 mg/mL (ultrasonic);H2O : < 0.1 mg/mL |
Ethoxysanguinarine is a benzophenanthridine alkaloid natural product that is mainly found in Macleaya cordata. Ethoxysanguinarine is an inhibitor of protein phosphatase 2A (CIP2A). Ethoxysanguinarine induces cell apoptosis and inhibits colorectal cancer cells growth[1].
IC50 & Target:Target: CIP2A, Apoptosis[1]
In Vitro: Ethoxysanguinarine inhibits cells vialibity with IC50 of 9.37 μM (SW480 cells); 7.19 μM (HCT116 cells); 6.55 μM (HT69 cells); 3.57 μM (SW620 cells)[1].
Ethoxysanguinarine (3 μM or 5 μM, 24 h) down-regulates phospho-Akt, decreases CIP2A/PP2A/Akt pathway expression in the SW620 and HT29 cells[1].
Ethoxysanguinarine (3 μM or 5 μM, 24 h) increases the PP2A activity and inhibits phosphorylation of CIP2A downstream molecule protein kinase B[1].
Ethoxysanguinarine (1-3 μM or 4.5-5 μM, 24 h) decreases CIP2A transcription (protein level) and induces CIP2A proteolysis in the SW620 and HT29 cells[1].
In Vivo: Ethoxysanguinarine (0.5 mg/kg; s.c.; 5 times per week; 4 weeks) represses colorectal cancer (CRC) xenograft tumors growth in mice[1].
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