WD2000-012547
CAS No. : 283172-68-9
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| Cat. No. : | HY-U00223 |
| M.Wt: | 262.31 |
| Formula: | C17H14N2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
WD2000-012547 is a selective poly(ADP-ribose)-polymerase (PARP-1) inhibitor with a pKi of 8.221. IC50 & Target: pKi: 8.221 (PARP-1)[1] In Vitro: Poly(ADP-ribose) polymerase-1 (PARP-1) functions as a DNA damage sensor and signaling molecule. It plays a vital role in the repair of DNA strand breaks induced by radiation and chemotherapeutic drugs; inhibitors of this enzyme have the potential to improve cancer chemotherapy or radiotherapy. WD2000-012547 (Compound 66) is a representative PARP-1 inhibitor with a pKi of 8.221[1].
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