HODHBt
CAS No. : 28230-32-2
(Synonyms: HOOBt)
| Size | Price | Stock |
|---|---|---|
| 5g | $25 | In-stock |
| 10g | $35 | In-stock |
| 25g | $55 | In-stock |
| 50g | $80 | In-stock |
| 100g | $130 | In-stock |
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| Cat. No. : | HY-Y0493 |
| M.Wt: | 163.14 |
| Formula: | C7H5N3O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 500 mg/mL (ultrasonic) |
HODHBt (HOOBt) inhibits STAT5-SUMO interaction by blocking SUMOylation of phosphorylated STAT5. HODHBt enhances the magnitude of IL-15 signaling and significantly increases the natural killer (NK) cell cytotoxicity phenotype and function and the generation of cytokine-induced memory-like (CIML) natural killer (NK) cells. HODHBt can be used for research of HIV-infection and cancer[1].
In Vitro: HODHBt (100 μM; 24 h, and 48 h respectively) increases IL-15-mediated STAT phosphorylation in NK cells and enhances the cytotoxic profile of NK cells[1].
HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL) cytotoxicity of NK cells against HIV-infected cells (K562 cells)[1].
HODHBt (100 μM; 24 h) enhances IL-15-mediated (100 ng/mL, 6 h) cytotoxicity of NK cells against cancer cell lines (A2780 and U877; OCILy1 and OCILy10)[1].
HODHBt (100 μM; 7 d) results in enhanced memory response upon recall in generation of human CIML NK cells in vitro[1].
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