GLP-1R agonist 2
CAS No. : 281209-71-0
| Size | Price | Stock |
|---|---|---|
| 1mg | $60 | In-stock |
| 5mg | $175 | In-stock |
| 10mg | $305 | In-stock |
| 25mg | $490 | In-stock |
| 50mg | $686 | In-stock |
| 100mg | $960 | In-stock |
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| Cat. No. : | HY-121835 |
| M.Wt: | 348.25 |
| Formula: | C13H15Cl2N3O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 60°C) |
GLP-1R agonist 2 (compound 2) is an effective GLP-1R agonist that exerts its activating effect by forming hydrogen bonds with the Tyr42, Cys71, and Ser84 residues of GLP-1R. GLP-1R agonist 2 has the potential for research in metabolic diseases such as type 2 diabetes and obesity[1]. In Vitro:GLP-1R agonist 2 (100 nM, 1,000 nM) activates GLP-1 receptor-mediated cAMP production, with an EC50 of 101 nM, but exhibits a self-limiting effect at high concentrations[2]. GLP-1R agonist 2 (100 nM) enhances GLP-1 binding to the GLP-1 receptor, reducing the Kd value from 0.51 nM to 0.19 nM[2]. GLP-1R agonist 2 (100 nM, 1,000 nM) promotes glucose-dependent insulin secretion in CD1 mouse islets, and this effect is dependent on the GLP-1 receptor. Specifically, at concentrations of 100 nM and 1,000 nM, GLP-1R agonist 2 significantly enhances 10 mM glucose-induced insulin secretion, similar to GLP-1, and this effect is abolished in islets from GLP-1 receptor knockout mice[2].
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