A-286982
CAS No. : 280749-17-9
| Size | Price | Stock |
|---|---|---|
| 1mg | $40 | In-stock |
| 5mg | $85 | In-stock |
| 10mg | $135 | In-stock |
| 25mg | $270 | In-stock |
| 50mg | $450 | In-stock |
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| Cat. No. : | HY-107587 |
| M.Wt: | 453.55 |
| Formula: | C24H27N3O4S |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic;warming;heat to 60°C) |
A-286982 is a potent and allosteric LFA-1/ICAM-1 interaction inhibitor with IC50s of 44 nM and 35 nM in an LFA-1/ICAM-1 binding and LFA-1-mediated cellular adhesion assay, respectively[1][2]. IC50 & Target: IC50: 44 nM (LFA-1/ICAM-1 interaction in an LFA-1/ICAM-1 binding assay) and 35 nM (LFA-1/ICAM-1 interaction in LFA-1-mediated cellular adhesion assay)[1] In Vitro: A-286982 binds to the I domain allosteric site (IDAS). The allosteric ICAM inhibition such as this would be expected to exhibit the unsurmountable competition we have observed for A-286982 as a result of the passage of this allostery through the A-286982 binding site in its transmission from the β subunit I-like domain to the α subunit ICAM binding site[2].
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