S-Trityl-L-cysteine
CAS No. : 2799-07-7
(Synonyms: NSC 83265; S-Tritylcysteine; 3-Tritylthio-L-alanine)
| Size | Price | Stock |
|---|---|---|
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| 25g | $23 | In-stock |
| 100g | $91 | In-stock |
| 500g | $394 | In-stock |
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| Cat. No. : | HY-W011102 |
| M.Wt: | 363.47 |
| Formula: | C22H21NO2S |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
S-Trityl-L-cysteine (NSC 83265) is a selective and allosteric kinesin Eg5 inhibitor with an IC50 of 1 μM for the inhibition of basal ATPase activity and 140 nM for the microtubule-activated ATPase activity. S-Trityl-L-cysteine has antitumor activities[1][2].
In Vitro: S-Trityl-L-cysteine binds to a unique pocket in the Eg5 motor domain formed by secondary structural elements (helix a2/loop L5/helix a3)[1].
S-Trityl-L-cysteine (1-20 µM; for 72 h) could mediate cell apoptosis, as well as cell cycle arrest, in a dose-dependent manner. S-Trityl-L-cysteine-mediated apoptosis and cell cycle arrest were triggered by activation of the mitogen-activated protein kinase and nuclear factor kB signaling pathways[1].
S-Trityl-L-cysteine induces mitotic arrest in HeLa cells (IC50 of 700 nM) with characteristic monoastral spindles[2].
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