Quinoclamine
CAS No. : 2797-51-5
| Size | Price | Stock |
|---|---|---|
| 50mg | $50 | In-stock |
| 100mg | $80 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-121632 |
| M.Wt: | 207.62 |
| Formula: | C10H6ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
Quinoclamine, a naphthoquinone derivative, is a NF-κB inhibitor. Quinoclamine exhibits anti-cancer activity[1][2].
IC50 & Target: NF-κB[2]
In Vitro: Quinoclamine causes differentiation of U-937 cells into macrophage-like cells[1].
Quinoclamine inhibits NF-κB activities in HepG2 cells, with an IC50 of 1.7 μM[2].
Quinoclamine (1-4 μM; 30 minutes ) suppresses endogenous NF-κB activity in HepG2 cells through the inhibition of IκB-α phosphorylation and p65 translocation[2].
Quinoclamine inhibits induced NF-κB activities in lung and breast cancer cell lines[2].
Quinoclamine affects the expression levels of genes involved in cell cycle or apoptosis[2].
Quinoclamine down-regulates the expressions of UDP glucuronosyltransferase genes involved in phase II drug metabolism[2].
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