Crocetin
CAS No. : 27876-94-4
(Synonyms: Transcrocetin; trans-Crocetin)
| Size | Price | Stock |
|---|---|---|
| 5mg | $80 | In-stock |
| 10mg | $140 | In-stock |
| 25mg | $250 | In-stock |
| 50mg | $375 | In-stock |
| 100mg | $560 | In-stock |
| 250mg | $1100 | In-stock |
| 500mg | $1650 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-N2072 |
| M.Wt: | 328.40 |
| Formula: | C20H24O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 20 mg/mL (ultrasonic) |
Crocetin (Transcrocetin) is an aglycone of crocin. Crocetin is an orally active and brain-penetrant. Crocetin shows strong NMDA receptor affinity and channel opening activity. Crocetin can downregulate the proinflammatory cytokines and COX-2 exoression. Crocetin can inhibit apoptosis and activation of MAPK. Crocetin can delay delays brain and body aging. Crocetin can be used for the researches of cancer, neurological disease and inflammation, such as cervical cancer and ischemia[1][2][3][4].
IC50 & Target:NMDA receptor[1]
In Vitro:Crocetin (1-100 μM, 24 h) inhibits COX-2 expression in HeLa cells[1].
In Vivo:Crocetin (10-40 mg/kg, p.o., twice a day for 35 days) shows preventive and an anti-inflammation effect in methylcholanthrene (MCA)-induced uterine cervix tumor mice models[1].
Crocetin (20 mg/kg, p.o., 1 h before ischemia) inhibits retinal ischemic damage in ischemia/reperfusion-induced mice models[2].
Crocetin (25 mg/mL, p.o., daily) delays brain and body aging in aged C57BL/6J mice[3].
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