Crocetin (Standard)

Crocetin (Standard) (TransCrocetin (Standard) ) is an aglycone of crocin. Crocetin (Standard) is orally active and brain-penetrant. Crocetin (Standard) shows strong NMDA receptor affinity and channel opening activity. Crocetin (Standard) can downregulate the proinflammatory cytokines and COX-2 exoression. Crocetin (Standard) can inhibit apoptosis and activation of MAPK. Crocetin (Standard) can delay delays brain and body aging. Crocetin (Standard) can be used for the researches of cancer, neurological disease and inflammation, such as cervical cancer and ischemia^[1][2][3][4]. IC50 & Target:NMDA receptor^[1] In Vitro:Crocetin (Standard) (1-100 μM, 24 h) inhibits COX-2 expression in HeLa cells^[1].
In Vivo:Crocetin (Standard) (10-40 mg/kg, p.o., twice a day for 35 days) shows preventive and an anti-inflammation effect in methylcholanthrene (MCA)-induced uterine cervix tumor mice models^[1].
Crocetin (Standard) (20 mg/kg, p.o., 1 h before ischemia) inhibits retinal ischemic damage in ischemia/reperfusion-induced mice models^[2].
Crocetin (Standard) (25 mg/mL, p.o., daily) delays brain and body aging in aged C57BL/6J mice^[3].