NH125
CAS No. : 278603-08-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $340 | In-stock |
| 50mg | $580 | In-stock |
| 100mg | $980 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-100576 |
| M.Wt: | 524.56 |
| Formula: | C27H45IN2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
NH125 is a potent and selective inhibitor of eukaryotic elongation factor 2 kinase (eEF-2K/CaMKIII) with an IC50 of 60 nM for eEF-2K. NH125 kills methicillin-resistant S. aureus (MRSA) persisters by interacting with and disrupting membranes[1][2]. IC50 & Target:IC50: 60 nM (eEF-2K/CaMKIII)[1]. In Vitro:NH125 inhibits eEF-2 kinase activity (IC50 = 60 nM) in vitro, blocks the phosphorylation of eEF-2 in intact cells, and shows relative selectivity over other protein kinases: protein kinase C (IC50 = 7.5 μM), protein kinase A (IC50 = 80 μM), and calmodulin-dependent kinase II (IC50 > 100 μM). NH125 decreases the viability of 10 cancer cell lines with IC50s ranging from 0.7 to 4.7 μM. Forced overexpression of eEF-2 kinase in a glioma cell line produces 10-fold resistance to NH125[1].
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