Uridine-5'-diphosphate disodium salt
CAS No. : 27821-45-0
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|---|---|---|
| 100mg | $20 | In-stock |
| 1g | $22 | In-stock |
| 5g | $68 | In-stock |
| 10g | $118 | In-stock |
| 25g | $267 | In-stock |
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| Cat. No. : | HY-W010832 |
| M.Wt: | 448.12 |
| Formula: | C9H12N2Na2O12P2 |
| Purity: | >98 % |
| Solubility: | H2O : 100 mg/mL (ultrasonic);DMSO : < 1 mg/mL |
Uridine-5'-diphosphate disodium salt is a potent, selective P2Y6 receptor native agonist (EC50=300 nM; pEC50=6.52 for human P2Y6 receptor). Uridine-5'-diphosphate disodium salt, an endogenous metabolite, catalyzes the glucuronidation of a wide array of substrates and is used in nucleic acid (RNA) biosynthesis[1][2].
IC50 & Target:EC50: 300 nM (P2Y6)[1]
pEC50: 6.52 (P2Y6)[1]
In Vitro: Uridine-5'-diphosphate disodium salt (100 μM; for 15 min) significantly induces microglial CCL2 and CCL3 mRNA expression[2].
Uridine-5'-diphosphate disodium salt (100 μM; 3 hours) induces chemokine expression in microglia[2].
Uridine-5'-diphosphate disodium salt (100 μM; 0.5, 1, 3, 6 12 hours) induces expression of mRNA encoding CCL2 and CCL3 within 30 min, and such expression reaches maximal levels at 1 h, returning to basal levels at 3-12 h[2].
Uridine-5'-diphosphate disodium salt (10, 100, 1000 μM; 3 hours) induces a concentration-dependent increase in the expression of chemokines at both the mRNA and protein level[2].
Uridine-5'-diphosphate disodium salt (100 μM; for 15 min) induces activation of NFATc1 and NFATc2 in microglia[2].
Uridine-5'-diphosphate disodium salt is a competitive antagonist at the human P2Y14 receptor (pEC50=7.28) but not rat P2Y14 receptor[1].
UDP-glucose (UDPG; HY-N7032) is a potent P2Y14 agonist[3][4].
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