Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium (chloride)

Dimethyloctadecyl[3-(trimethoxysilyl) propyl]ammonium chloride is a quaternary ammonium silane monomer-based disinfectant/antimicrobial agent. Dimethyloctadecylammonium chloride exhibits bactericidal activity against Gram-positive and Gram-negative bacteria, as well as fungicidal activity against Candida albicans in solution; it can form a hydrophobic glass coating that displays bactericidal activity against Gram-positive and Gram-negative bacteria but has limited fungicidal activity against Candida albicans^[1]. In Vitro:Dimethyloctadecyl[3-(trimethoxysilyl) propyl]ammonium chloride (24 h) acts as a bactericide against Staphylococcus aureus (MIC = 3.9 μg/mL, MBC = 3.9 μg/mL) and Escherichia coli (MIC = 62.5 μg/mL, MBC = 62.5 μg/mL), and also functions as a fungicide against Candida albicans (MIC = 15.6 μg/mL, MFC = 62.5 μg/mL)^[1].
Dimethyloctadecyl[3-(trimethoxysilyl) propyl]ammonium chloride (62.5 μg/mL; 24 h) exhibits high toxicity toward human skin fibroblasts, HaCaT keratinocytes and HEK293 cells^[1].
The coating formed on the surfaces of glass coverslips and Lava™ Ultimate dental restorative material by dimethyloctadecyl[3-(trimethoxysilyl) propyl]ammonium chloride (10 mg/mL; 24 h) exhibits strong antibacterial activity against Staphylococcus aureus and Escherichia coli, but shows negligible activity against Candida albicans^[1].