BMS-223131
CAS No. : 275375-69-4
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| Cat. No. : | HY-19397 |
| M.Wt: | 383.75 |
| Formula: | C18H13ClF3NO3 |
| Purity: | >98 % |
| Solubility: |
BMS-223131 (Compound 1) is a potent maxi-K potassium channel opener. BMS-223131 has a strong inhibitory effect on the CYP2C9 enzyme (IC50 = 1.7 μM) and also shows varying degrees of inhibition on other common CYP enzymes such as CYP1A2, CYP2C19, CYP2D6, and CYP3A4. BMS-223131 can enhance the outward current mediated by maxi-K, by promoting K+ efflux to hyperpolarize the cell membrane and reducing Ca2+ influx. BMS-223131 can be used for the research of neurological disease, such as stroke[1].
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