4α-Phorbol 12,13-didecanoate
CAS No. : 27536-56-7
(Synonyms: 4αPDD)
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| Cat. No. : | HY-116291 |
| M.Wt: | 672.93 |
| Formula: | C40H64O8 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
4α-Phorbol 12,13-didecanoate (4αPDD) is a transient receptor potential vanilloid 4 (TRPV4) agonist. 4α-Phorbol 12,13-didecanoate can promote Ca2+ influx, induce ATP release and function as an osmoreceptor. 4α-Phorbol 12,13-didecanoate can inhibit water intake and increase maximal micturition pressure in rats. 4α-Phorbol 12,13-didecanoate can be used for the researches of inflammation and infection, such as chikungunya virus (CHIKV)[1][2][3][4].
In Vitro:4α-Phorbol 12,13-didecanoate (10-50 μM) increases ATP release in urothelial cells[2].
4α-Phorbol 12,13-didecanoate (1-10 μM) increases Ca2+ in DRG neurons[3].
4α-Phorbol 12,13-didecanoate shows antiviral activities against CHIKV with an EC50 value of 1.5 μM[4].
In Vivo:4α-Phorbol 12,13-didecanoate (20 μg, intracerebroventricular injection) inhibits water intake in WT rats[1].
4α-Phorbol 12,13-didecanoate (10-100 μM, intravesically administration) increases maximal micturition pressure in rats[2].
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