Troleandomycin
CAS No. : 2751-09-9
(Synonyms: Triacetyloleandomycin)
| Size | Price | Stock |
|---|---|---|
| 1mg | $190 | In-stock |
| 5mg | $530 | In-stock |
| 10mg | $850 | In-stock |
| 25mg | $1530 | In-stock |
| 50mg | $2448 | In-stock |
| 100mg | $3918 | In-stock |
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| Cat. No. : | HY-108881 |
| M.Wt: | 813.97 |
| Formula: | C41H67NO15 |
| Purity: | >98 % |
| Solubility: | DMSO : 83.33 mg/mL (ultrasonic) |
Troleandomycin (Triacetyloleandomycin), a macrolide acrolide antibiotic, is a selective CYP3A inhibitor. Troleandomycin is an oral corticosteroid for asthma study[1][2][3].
In Vitro: Troleandomycin markedly inhibits 6β-hydroxylation of testosterone, 25- and 26-hydroxylations of 5β-cholestane-3α,7α,12α-triol and 23R-, 24R-, 24S-, and 27-hydroxylations of 5β-cholestane-3α,7α,12α,25-tetrol in both recombinant CYP3A4 and microsomes, but IC50 values for microsomes are somewhat higher than those for recombinant CYP3A4[1].
In Vivo: Troleandomycin markedly suppresses these microsomal side chain hydroxylations in both mouse and human livers in a dose-dependent manner[2].
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