Tirapazamine
CAS No. : 27314-97-2
(Synonyms: SR259075; SR4233; Win59075; SML 0552; SR 259075; Tirazone)
| Size | Price | Stock |
|---|---|---|
| 50mg | $79 | In-stock |
| 100mg | $145 | In-stock |
| 200mg | $264 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-13767 |
| M.Wt: | 178.15 |
| Formula: | C7H6N4O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
Tirapazamine (SR259075) is an anticancer agent that shows selective cytotoxicity for hypoxic cells in solid tumors, thereby inducing single-and double-strand breaks in DNA, base damage, and cell death. Tirapazamine is an anticancer and bioreductive agent.Tirapazamine (SR259075) can enhance the cytotoxic effects of ionizing radiation in hypoxic cells[1][2]. In Vitro:Tirapazamine (SR259075) is the optimal drug for combination therapy using Pba[1]. In Vivo:Tirapazamine (SR259075) (1mg; intravenously injected; twice at a 24-h interval) shows a synergetic effect to kill tumor cells because TPZ was activated under the hypoxic conditions that originated from the PDT with Pba and laser irradiation[1]..
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