ICI-63197
CAS No. : 27277-00-5
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| Cat. No. : | HY-103024 |
| M.Wt: | 207.23 |
| Formula: | C9H13N5O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
ICI-63197 is a phosphodiesterase 3 (PDE3) and PDE4 inhibitor with Ki values of 9 µM and 10 µM, respectively. ICI-63197 is selectivity against PDE1 and PDE2. ICI-63197 has antidepressant effects[1][2].
In Vitro:In rabbit isolated pulmonary artery previously incubated with [3H]-noradrenaline, ICI-63197 (30 μM) significantly enhances the stimulation-induced outflow of radioactivity[3].
At a stimulation frequency of 2 Hz in mouse atria, ICI-63197 (30 μM) shows no effect on the stimulation-induced outflow[3].
In Vivo:Thirty and ninety minutes after intraperitoneal administration, ICI 63197, 0.48-29.9 µmol/kg, dose-dependently antagonized the Reserpine induced hypothermia in mice[2].
ICI-63197 potentiates the locomotor stimulatory effect of dopamine or of the ergot dopamine agonist Lisuride administered directly into the nucleus accumbens of rats. ICI-63197 has property of enhancing central noradrenergic transmission[2].
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