β-Rubromycin
CAS No. : 27267-70-5
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| Cat. No. : | HY-122482 |
| M.Wt: | 536.44 |
| Formula: | C27H20O12 |
| Purity: | >98 % |
| Solubility: | DMSO : 1 mg/mL (ultrasonic;warming) |
β-Rubromycin, a quinone antibacterial agent, is a selective HIV-1 reverse transcriptase inhibitor with a Ki of 0.27 μM. β-Rubromycin is a potent telomerase inhibitor with an IC50 of 3 μM. β-Rubromycin inhibits the proliferation of both K-562 and HeLa cells with IC50 values of 19.5 µM and 22.7 µM, respectively[1][2].
IC50 & Target:reverse transcriptase[1]
In Vitro:β-Rubromycin inhibits equipotently HIV-1 RT and avian myeloblastosis virus RT, in a concentration-dependent manner, and is significantly weaker as an inhibitor of calf thymus DNA polymerase α[1].
A kinetic study of the inhibition by β-Rubromycin revealed a competitive interaction with respect to the telomerase substrate primer, with a Ki of 0.74 μM, whereas a mixed type inhibition was observed with respect to the nucleotide substrate[2].
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