Econazole

Econazole ((±)-Econazol) is an orally active imidazole antifungal agent, as well as a cytochrome P-450 inhibitor and a blocker of calcium and manganese ion uptake. Econazole is active against a variety of fungi and some Gram-positive bacteria, but has no significant activity against Gram-negative bacteria. Econazole can inhibit the synthesis of prostaglandins and can also induce liver damage^{[1][2][3][4][5]}. In Vitro:Econazole (0-30 μM; 40 min) can inhibit the production of PGE₂ (HY-101952) induced by multiple stimulants in MC3T3-E1 cells^[1].
Econazole (25 μM; 2-3 min) can effectively inhibit the calcium ion influx and manganese ion uptake induced by Thapsigargin (HY-13433) in rat thymic lymphocytes^[2].
Econazole (3-30 μM) can inhibit TRPM2-mediated currents in HEK-293 cells expressing hTRPM2^[3]. In Vivo:Econazole (oral administration) has LD₅₀ values of 463-520 mg/kg, 668-920 mg/kg, 252-272 mg/kg, 160 mg/kg in mice, rats, guinea pigs, and dogs^[4].
Econazole (100-300 mg/kg; oral administration; single dose) can induce liver injury in rats^[5].