Monocalcium glycerophosphate

Monocalcium glycerophosphate is an inhibitor of intestinal alkaline phosphatase F3, and it has anti-cavity properties. Monocalcium glycerophosphate is a source of calcium and phosphorus in total parenteral nutrition solutions, helps prevent the mineralization and development of bones from intravenous nutrition, and maintains the integrity of the intestinal epithelium^[1][2][3]. In Vitro:Monocalcium glycerophosphate (1-1000 μM, 0-24 h) protects trans-epithelial electrical resistance (TEER) in Caco-2 cells and reduces the increase in mannitol permeability rate^[1].
Monocalcium glycerophosphate (0.10%, 0.25%, 0.50%) significantly decreases the level of demineralization in an in vitro bacterial flow chamber model^[2]. In Vivo:Monocalcium glycerophosphate (at a concentration that meets the needs for intravenous injection in piglets of 15 mmol Ca and 15 mmol P/kg/day, via jugular catheterization, seven days) can serve as an effective source of calcium and phosphorus in piglet TPN solutions, preventing the development of bone mineralization from intravenous nutrition^[3].