| Size | Price | Stock |
|---|---|---|
| 1mg | $166 | In-stock |
| 5mg | $260 | In-stock |
| 10mg | $420 | In-stock |
| 50 mg | Get quote | |
| 100 mg | Get quote | |
| We match the lowest price on market. | ||
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| Cat. No. : | HY-N1951 |
| M.Wt: | 282.38 |
| Formula: | C19H22O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC50 of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; Ki = 0.04 μM) and SARS-CoV main protease (Mpro)[1][2][3][4].
IC50 & Target:IC50s: 3C-like protease (3CLpro) (21.1 μM), papain-like protease (PLpro) (30 μM)
In Vitro:Miltirone (0-100 μM, 48 h) induces ROS - and-p53 dependent apoptosis in colon cancer cells[2].
Miltirone (3.13-25 μM, 1-24 h) induces translocation of apoptosis-inducing factor (AIF) in colon cancer cells[2].
In Vivo:Miltirone (10-60 mg/kg, p.o.; one hour before test) increases the number of punished crossings in the four-plate test in mice[1].
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