Miltirone


CAS No. : 27210-57-7

(Synonyms: Rosmariquinone)

27210-57-7
Price and Availability of CAS No. : 27210-57-7
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1mg $166 In-stock
5mg $260 In-stock
10mg $420 In-stock
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Cat. No. : HY-N1951
M.Wt: 282.38
Formula: C19H22O2
Purity: >98 %
Solubility: DMSO : 50 mg/mL (ultrasonic)
Introduction of 27210-57-7 :

Miltirone is an orally active natural compound found in the root of Salvia miltiorrhiza. Miltirone is a central benzodiazepine receptor partial agonist, with an IC50 of 0.3 μM. Miltirone induces ROS - and-p53 dependent apoptosis. Miltirone inhibits carboxylesterase 2 (CES2; Ki = 0.04 μM) and SARS-CoV main protease (Mpro)[1][2][3][4]. IC50 & Target:IC50s: 3C-like protease (3CLpro) (21.1 μM), papain-like protease (PLpro) (30 μM) In Vitro:Miltirone (0-100 μM, 48 h) induces ROS - and-p53 dependent apoptosis in colon cancer cells[2].
Miltirone (3.13-25 μM, 1-24 h) induces translocation of apoptosis-inducing factor (AIF) in colon cancer cells[2].
In Vivo:Miltirone (10-60 mg/kg, p.o.; one hour before test) increases the number of punished crossings in the four-plate test in mice[1].

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