LY393558
CAS No. : 271780-64-4
| Size | Price | Stock |
|---|---|---|
| 1mg | $77 | In-stock |
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| Cat. No. : | HY-103089 |
| M.Wt: | 546.68 |
| Formula: | C26H31FN4O4S2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
LY393558 is a potent and orally active inhibitor of the 5-HT transporter and an antagonist of 5-HT1B and 5-HT1D receptors. LY393558 increase the extracellular levels of 5-HT in mice model frontal cortex. LY393558 can be used for researching depression[1].
In Vivo: LY393558 (1-20 mg/kg; p.o., single) raises extracellular levels of 5-HT to 200-250% at 1 mg/kg in guinea pigs model, while levels of 5-HT to approximately 1500% at the highest dose 20 mg/kg[1].
LY393558 (20 mg/kg; p.o., single) completely abolishes the reduction of levels of 5-HT induced by tetrodotoxin (1μM) in guinea pigs model[1].
LY393558 (1-20 mg/kg; p.o., single) significantly increases extracellular levels of 5-HT in rats model[1].
LY393558 (5 mg/kg/day; p.o., 21 days) can still elicit a further increase in extracellular 5-HT in chronic treatment[1].
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