MMK1
CAS No. : 271246-66-3
| Size | Price | Stock |
|---|---|---|
| 1mg | $130 | In-stock |
| 5mg | $350 | In-stock |
| 10mg | $560 | In-stock |
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| Cat. No. : | HY-P1117 |
| M.Wt: | 1610.96 |
| Formula: | C75H123N19O18S |
| Purity: | >98 % |
| Solubility: | DMSO : 16.67 mg/mL (ultrasonic) |
MMK1 is a potent and selective human formyl peptide receptor like-1 (FPRL-1/FPR2) agonist with EC50s of <2 nM and >10000 nM for FPRL-1 and FPR1, respectively. MMK1 is a potent chemotactic and calcium-mobilizing agonist. MMK1 potently activates phagocytic leukocytes and enhances Pertussis Toxin-sensitive production by human monocytes of proinflammatory cytokines IL-1b and IL-6. MMK1 exerts anxiolytic-like activity[1][2][3][4].
In Vitro:MMK-1 induces calcium mobilization in human FPRL1-transfected HEK 293 (FPRL1/293) cells with an EC50 of 2 nM[1].
MMK1 (1?μM; for 4?h) induces selective migration of FPR2-expressing RBL-2H3 cells[3].
In Vivo:MMK1 (10-1000 pmol; ICV; 20 min before the test) exerts an aniolytic-exerted an anxiolytic-like activity at a dose of 100 pmol/mouse[4].
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