Spiclomazine (hydrochloride)
CAS No. : 27007-85-8
(Synonyms: APY-606; Clospirazine (hydrochloride))
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| Cat. No. : | HY-122152 |
| M.Wt: | 482.49 |
| Formula: | C22H25Cl2N3OS2 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Spiclomazine hydrochloride (APY-606) is an antipsychotic and antitumor agent. Spiclomazine hydrochloride inhibits KRas. Spiclomazine hydrochloride induces cancer cell apoptosis[1][2].
In Vitro:Spiclomazine (0-100 μg/mL; 24 and 48 h) hydrochloride inhibits contact-independent colony formation of pancreatic carcinoma cells in a dose-dependent manner[1].
Spiclomazine (0.5x and 1x IC50; 48 h) hydrochloride induces CFPAC-1 and MIA PaCa-2 cells apoptosis in the mitochondrial pathway, and significantly enhanced intracellular ROS level[1].
Spiclomazine (30 μg/mL; 24 h) hydrochloride suppresses cellular motility in CFPAC-1 and MIA PaCa-2 cells[1].
Spiclomazine (10 and 20 μg/mL; 24 h) hydrochloride arrests cancer cell cycle progression at G2 phase[2].
In Vivo:Spiclomazine (68 mg/kg; i.p.; every other day for two weeks) hydrochloride reduces the growth of MIA PaCa-2 xenograft in mice[2].
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