AAL993
CAS No. : 269390-77-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $185 | In-stock |
| 25mg | $350 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $880 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-19986 |
| M.Wt: | 371.36 |
| Formula: | C20H16F3N3O |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
IC50s of 130 nM, 23 nM, and 18 nM for VEGFR1, VEGFR2, and VEGFR3, respectively. AAL993 shows less potently inhibits other tyrosine kinases. AAL993 possesses potent antiangiogenic and antitumor properties[1].
In Vitro: AAL993 suppresses HIF-1α expression through ERK inhibition without affecting Akt phosphorylation[2].
In Vivo: AAL993 (compound 5) potently inhibits VEGF-induced angiogenesis in an implant model, with an ED50 value of 7 mg/kg[1].
In B16 melanoma xenograft model, AAL993 (24-100 mg/kg; p.o.; daily; for 14days) inhibits both the growth of the primary tumor as well as the formation of spontaneous peripheral metastases[1].
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