(S)-Timolol (maleate)
CAS No. : 26921-17-5
(Synonyms: (S)-L-714,465 (maleate); MK 950)
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| Cat. No. : | HY-17380 |
| M.Wt: | 432.49 |
| Formula: | C17H28N4O7S |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic);H2O : 50 mg/mL (ultrasonic) |
(S)-Timolol Maleate (L-714,465 Maleate) is a non-cardioselective hydrophilic β-adrenoceptor blocker. (S)-Timolol Maleate is widely used as standard medication for intraocular pressure (glaucoma) by preventing the production of aqueous humor. (S)-Timolol Maleate can be used for hypertension, angina pectoris and myocardial infarction[1][2][3]. IC50 & Target:Ki: 1.97 nM (β1-adrenoceptor); 2.0 nM (β2-adrenoceptor) In Vitro: Timolol maleate represents a chiral compound with one asymmetric carbon in its structure. Single isomer, (S)-enantiomer, is a non-cardioselective β-adrenergic blocker. Its commonest application is in topical treatment of increasing intraocular pressure in patients with chronic open angle glaucoma and also in aphakic patients[1]. In Vivo: There are reports that indicate lower biological activity of (R)-isomer compared to (S)-isomer. Namely, (R)-timolol is 49 times less potent than (S)-timolol on β-adrenoceptor in animals, 13 times less potent in constricting the airways of normal subjects[1].
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