NBI-34041
CAS No. : 268545-87-5
(Synonyms: SB-723620)
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| Cat. No. : | HY-14128 |
| M.Wt: | 417.37 |
| Formula: | C22H26Cl2N4 |
| Purity: | >98 % |
| Solubility: |
NBI-34041 (SB-723620) is a selective and orally active nonpeptide CRF1 receptor antagonist with an IC50 of 58.9 nM and a Ki of 4.0 nM for human CRF1 receptor. NBI-34041 has no inhibitory effect on the CRF2 receptor. NBI-34041 can be used for depression and anxiety disorders research. In Vitro:NBI-34041 could inhibit the production of cAMP in a concentration-dependent manner with an IC50 of approximately 60 nM. At concentrations of NBI-34041 up to 10 000 nM, NBI-34041 is unable to fully inhibit sauvagine stimulated cAMP from cells expressing the human CRF2 receptor[1]. In Vivo:NBI-34041 (3-30 mg/kg; oral gavage; a single dose) significantly attenuates the elevation in plasma ACTH induced by CRF. NBI-34041 also demonstrates efficacy in attenuating shock-induced ACTH release in a dose-dependent manner[1].
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