Methylisothiazolinone (Standard)

Methylisothiazolinone (Standard) is the analytical standard of Methylisothiazolinone. Methylothiazolinone is a fungicide and preservative, as well as a sensitizer. Methylisothiazolinone can activate matrix metalloproteinases (MMPs) in human bronchial epithelial cells to induce cell apoptosis and inflammatory response. Methylisothiazolinone can promote the development of atopic dermatitis in mice by disrupting Th2/Th17 related immune responses. Methylisothiazolinone can cause mitochondrial damage in the endothelium of rat cerebral blood vessels^[1][2][4].
In Vitro:Methylisothiazolinone (0-8 μg/mL, 24 h) 通过激活人支气管上皮细胞中的基质金属蛋白酶 (MMPs) 来诱导细胞凋亡和炎症反应^[1]。
Methylisothiazolinone (0-2.5 μg/mL, 1 h) 可以引起脑内皮细胞中的线粒体损伤^[2]。
In Vivo:Methylisothiazolinone (0.15 mg/kg; once; i.v.) can increase the susceptibility of rat cerebral vascular endothelium to endogenous pathological stimuli and lead to mitochondrial damage^[2].
Methylisothiazolinone (20 or 40 μL; handling skin (20 μL), days 1 and 8; intranasal instillation (40 μL), day 15) can cause sensitization and respiratory immune response in asthmatic mice after skin treatment^[3].
Methylisothiazolinone (0.1875 mg/kg; once daily; 15 days; epidermal contact) promotes the development of atopic dermatitis in mice through Th2/Th17 related immune response dysregulation^[4].