[Nphe1]Nociceptin(1-13)NH2


CAS No. : 267234-08-2

267234-08-2
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Cat. No. : HY-P1320
M.Wt: 1381.59
Formula: C61H100N22O15
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 267234-08-2 :

[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2?binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent[1]. In Vitro: [Nphe1]nociceptin(1-13)NH2?binds selectively to recombinant nociceptin receptors expressed in Chinese hamster ovary (CHO) cells (pKi=8.4) and competitively antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0).

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