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|---|---|---|
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| 500 mg | Get quote | |
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| Cat. No. : | HY-P1320 |
| M.Wt: | 1381.59 |
| Formula: | C61H100N22O15 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
[Nphe1]Nociceptin(1-13)NH2, a novel nociceptin/orphanin FQ (NC) endogenous ligand, is a selective and competitive ociceptin receptor antagonist without any residual agonist activity. [Nphe1]nociceptin(1-13)NH2?binds selectively to recombinant nociceptin receptors (pKi=8.4) and antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0). [Nphe1]Nociceptin(1-13)NH2 has the potential to act as an analgesic agent[1]. In Vitro: [Nphe1]nociceptin(1-13)NH2?binds selectively to recombinant nociceptin receptors expressed in Chinese hamster ovary (CHO) cells (pKi=8.4) and competitively antagonizes the inhibitory effects of nociceptin on cyclic AMP accumulation in CHO cells (pA2=6.0).
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