Succinyl phosphonate


CAS No. : 26647-82-5

26647-82-5
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Cat. No. : HY-12688
M.Wt: 182.07
Formula: C4H7O6P
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 26647-82-5 :

Succinyl phosphonate is an α-ketoglutarate dehydrogenase (KGDHC) inhibitor, effective inhibits (KGDHC) in muscle, bacterial, brain, and cultured human fibroblasts[1][4]. Succinyl phosphonate trisodium salt is an 2-oxoglutarate dehydrogenase (OGDH) inhibitor, impairs viability of cancer cells in a cell-specific metabolism-dependent manner[2]. Succinyl phosphonate trisodium salt inhibits the glutamate-induced ROS production in glutamate-stimulated hippocampal neurons in situ[3]. IC50 & Target:α-ketoglutarate dehydrogenase; 2-oxoglutarate dehydrogenase[1][4]; ROS production[3]

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