Ryuvidine
CAS No. : 265312-55-8
| Size | Price | Stock |
|---|---|---|
| 1mg | $80 | In-stock |
| 5mg | $180 | In-stock |
| 10mg | $265 | In-stock |
| 25mg | $448 | In-stock |
| 50mg | $672 | In-stock |
| 100mg | $940 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-100624 |
| M.Wt: | 284.33 |
| Formula: | C15H12N2O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 12.5 mg/mL (ultrasonic;warming;heat to 60°C) |
Ryuvidine is a potent inhibitor of SET domain-containing protein 8(SETD8) with an IC50 of 0.5 µM and suppresses monomethylation of H4K20. Ryuvidine also inhibits CDK4 with an IC50 of 6.0 μM. Ryuvidine also inhibits KDM5A and blocks DNA synthesis. Ryuvidine has anticancer activity against tumors such as breast cancer. Ryuvidine improves arthritis[1][2][3][4][5].
In Vitro:Ryuvidine (1-20 µM, 1-9 h) reduces CDC7 levels and blocks DNA synthesis in HeLa cells[3].
Ryuvidine (48 h) strongly inhibits KAIMRC2 (a breast cancer cell line) cell growth at an IC50 value of 0.8 µM[4].
In Vivo:Ryuvidine ameliorates arthritis pathogenesis in arthritis model mice[5].
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