Fosaprepitant (dimeglumine)


CAS No. : 265121-04-8

(Synonyms: MK-0517; L785298)

265121-04-8
Price and Availability of CAS No. : 265121-04-8
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250mg $51 In-stock
1g $131 In-stock
5g $406 In-stock
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Cat. No. : HY-14407A
M.Wt: 1004.83
Formula: C37H56F7N6O16P
Purity: >98 %
Solubility: H2O : 50 mg/mL (ultrasonic);10 mM in DMSO
Introduction of 265121-04-8 :

Fosaprepitant dimeglumine (MK-0517) is a prodrug of Aprepitant (HY-10052). Fosaprepitant dimeglumine is a neurokinin-1 receptor antagonist, which is development for the prevention of chemotherapy-induced nausea and vomiting (CINV)[1]. IC50 & Target: Neurokinin-1 receptor[1] In Vivo: Fosaprepitant dimeglumine (30 mg/kg; i.p.; daily; for 7 days) attenuates tolerance to morphine and increases the antinociceptive effect in in rats[1].

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