Edonentan (hydrate)
CAS No. : 264609-13-4
(Synonyms: BMS 207940 (hydrate))
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| Cat. No. : | HY-15402D |
| M.Wt: | 554.66 |
| Formula: | C28H34N4O6S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Edonentan (BMS 207940) hydrate is a potent and selective antagonist of the endothelin A (ETA) receptor, with a Ki of 10 pM. In rats, Edonentan has superior (100%) oral bioavailbility[1].
In Vivo:Edonentan (3-10 µmol/kg, orally) blocks big ET-1 pressor responses[1].
Edonentan (BMS 207940) shows improved systemic clearance (Cl) and steady-state volume of distribution (Vss) in comparison to BMS-193884 (HY-19263)[1].
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