CID 2745687
CAS No. : 264233-05-8
| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | In-stock |
| 10mg | $160 | In-stock |
| 25mg | $350 | In-stock |
| 50mg | $550 | In-stock |
| 100mg | $950 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-107537 |
| M.Wt: | 395.43 |
| Formula: | C17H19F2N5O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
CID 2745687 acts as a specific, reversible and competitive GPR35 antagonist with a Ki of 12.8 nM[1].
In Vitro: For ERK1/2 phosphorylation with 1 μM Pamoic acid as the agonist, the CID 2745687 (CID2745687) Ki is 18 nM[1].
CID 2745687 (CID-2745687) is a potent antagonist in β-arrestin-2 interaction assays only at human GPR35[2].
Using the BRET-based GPR35-β-arrestin-2 interaction assay and an EC80 concentration of Zaprinast (20 μM) as agonist, CID 2745687 behaved as a moderately potent, concentration-dependent antagonist at human GPR35 with pIC50=6.70±0.09[2].
CID 2745687 (pIC50=6.27±0.08) fully reverses the agonist action of Cromolyn disodium [2].
In Vivo: CID 2745687 (CID2745687; 1 mg/kg; administrated orally every day for the last 4 weeks), a specific GPR35 antagonist, reverses Lodoxamide-mediated anti-fibrotic effects[3].
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