GSK3987
CAS No. : 264206-85-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $130 | In-stock |
| 5mg | $260 | In-stock |
| 10mg | $420 | In-stock |
| 25mg | $720 | In-stock |
| 50mg | $1100 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-123402 |
| M.Wt: | 384.43 |
| Formula: | C24H20N2O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
GSK3987 is a pan LXRα/β agonist with EC50s of 50 nM, 40 nM for LXRα-SRC1 and LXRβ-SRC1, respectively. GSK3987 increases the expression of ABCA1 and SREBP-1c. GSK3987 induces cellular cholesterol efflux and triglyceride accumulation[1].
IC50 & Target: EC50: 50 nM (LXRα); 40 nM (LXRβ)[1]
In Vitro: GSK3987 (compound 4) shows activity with EC50s of 0.08 µM, 50 nM, 40 nM for ABCA1, LXRα-SRC1, LXRβ-SRC1, respectively[1].
GSK3987 (30, 100, 300, 1000 nM) increases the expression of ABCA1 and induces cellular cholesterol efflux to apoA1 particles in a dose-dependent manner in primary human macrophages[1].
GSK3987 (6-1500 nM) increases the expression of SREBP-1c and induces triglyceride accumulation in human hepatoma (HepG2) cells in a dose-dependent manner[1].
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