l-Pindolol
CAS No. : 26328-11-0
(Synonyms: (-)-Pindolol; (S)-(-)-Pindolol; S-Pindolol)
| Size | Price | Stock |
|---|---|---|
| 5mg | $156 | In-stock |
| 10mg | $250 | In-stock |
| 25mg | $500 | In-stock |
| 50mg | $800 | In-stock |
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| 200 mg | Get quote | |
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| Cat. No. : | HY-100606 |
| M.Wt: | 248.32 |
| Formula: | C14H20N2O2 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
l-Pindolol ((-)-pindolol) is a reversible, competitive and orally active 5-HT1A/1B antagonist. l-Pindolol is a partial β-adrenoceptor agonist. l-Pindolol can be used for the research of neurological disease[1][2][3]. In Vitro:l-Pindolol (500 nM and 1 μM) antagonizes the hyperpolarizing effect of both 5-carboxamidotryptamine (5-CT; 10 nM) and 5-Hydroxytryptamine (5-HT; 15 μM) by testing the membrane hyperpolarization induced by 5-CT or 5-HT on CA1 pyramidal cells[1]. l-Pindolol (1 nM-100 μM) inhibits the hyperpolarization in the hippocampus of CA1 pyramidal cells that induced by 100 nM 5-CT with an IC50 value of 92 nM[1]. l-Pindolol (1 nM-100 μM) inhibits the hyperpolarization of CA3 neurones induced by 300 nM 5-CT with an IC50 value of 522 nM[1]. In Vivo:l-Pindolol (15 mg/kg; i.p., pretreatment before [3H]-WAY 100635 injection) reduces [3H]-WAY 100635 accumulation of 5-HT1A receptor-containing brain areas[1].
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