Reticulol
CAS No. : 26246-41-3
(Synonyms: K 251-1)
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| Cat. No. : | HY-120241 |
| M.Wt: | 222.19 |
| Formula: | C11H10O5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Reticulol (K 251-1) is an inhibitor of cyclic adenosine 3', 5'-monophosphate phosphodiesterase. Reticulol shows antitumor activity independent with cell cycle arrest or apoptosis. Reticulol inhibits cell growth of murine melanoma cells and human lung tumor cells. Reticulol protects its lung metastasis via the bloodstream by inhibiting the growth of B16F10 melanoma[1][2]. In Vitro:Reticulol (25-200 μM) shows a potent cytotoxicity against the human lung tumor cell line A427 and the mouse melanoma cell line B16F10[1]. In Vivo:Reticulol (10 mg/kg, 50 mg/kg; iv; day 3 and day 5 after tumor implanted) inhibits tumor growth in mice bearing B16F10 melanoma, and shows lung metastasis-blocking effect[1].
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