Pericyazine

Pericyazine (Propericiazine) is a first-generation antipsychotic agent that is used as an adjunct to the short-term management of severe anxiety states and psychosis^[1]. Pericyazine is a selective D2-dopamine receptor antagonist^[2][3]. Pericyazine has adrenolytic, anticholinergic, and extrapyramidal effects^[4]. IC50 & Target: D2-dopamine receptor^[2] In Vivo: Studies in rodents show that Pericyazine is able to produce potentiation of ether and hexobarbital narcosis and morphine analgesia. It also has hypothermic activity and produces depression of spontaneous motor activity in mice. On a milligram potency basis, Pericyazine is more potent than chlorpromizine in the potentiation of barbiturate narcosis test and the blocking of conditioned avoidance in rats. Pericyazine demonstrates analgesic properties similar to methotrimeprazine in mice and rats and produces adrenergic blocking effects in mice and dogs^[4].