Soraprazan
CAS No. : 261944-46-1
(Synonyms: BYK61359)
| Size | Price | Stock |
|---|---|---|
| 1mg | $180 | In-stock |
| 5mg | $540 | In-stock |
| 10mg | $900 | In-stock |
| 25mg | $1800 | In-stock |
| 50mg | $2520 | In-stock |
| 100mg | $3960 | In-stock |
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| Cat. No. : | HY-100414 |
| M.Wt: | 367.44 |
| Formula: | C21H25N3O3 |
| Purity: | >98 % |
| Solubility: | DMSO : 200 mg/mL (ultrasonic) |
Soraprazan (BYK61359) is a selective, reversible K-competitive inhibitor of the H,K-ATPase (Ki=6.4 nM), with an IC50 of 0.19 μM in gastric glands. Soraprazan binds to the H,K-ATPase with a Kd of 28.27 nM. Soraprazan shows immediate inhibition of acid secretion and is more than 2000-fold selective for H,K-ATPase over Na,K- and Ca-ATPases[1]. In Vitro: Soraprazan (BYK61359) is a potent inhibitor of gastric H,K-ATPase, with an IC50 of 0.1 μM when measured in ion-leaky vesicles in the presence of 1 mM potassium. Soraprazan (BYK61359) also effectively inhibits dibutyryl cAMP-stimulated [14C]AP accumulation in isolated gastric glands with an IC50 of 0.19 μM (0.09-0.40 μM geometric mean from n=6 with 95% confidence limits)[1]. In Vivo: Soraprazan (1-27 μmol/kg; p.o.) shows rapid and consistent inhibition of acid secretion in dog [1].
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