PDE5-IN-16
CAS No. : 261769-44-2
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| Cat. No. : | HY-114797 |
| M.Wt: | 450.93 |
| Formula: | C23H23ClN6O2 |
| Purity: | >98 % |
| Solubility: |
PDE5-IN-16 is a selective phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 0.8 nM. PDE5-IN-16 enhances the relaxation of corpus cavernosum tissue strips. PDE5-IN-16 is applicable for the research of erectile dysfunction[1]. In Vitro:PDE5-IN-16 (Compound 5) potently inhibits human platelet PDE5 with an IC50 of 0.8 nM and exhibits high selectivity over bovine heart PDE1, rat kidney PDE2, human platelet PDE3, rat kidney PDE4, and bovine retina PDE6[1]. In Vivo:PDE5-IN-16 (Compound 5) (10-250 mg/kg; p.o.) shows no drug-related adverse effects in Rattus norvegicus at oral doses up to 50 mg/kg, with only mild body weight reduction in male rats at 250 mg/kg[1].
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