LM-4108
CAS No. : 261766-32-9
(Synonyms: N-(2-Phenylethyl)-indomethacin amide)
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| Cat. No. : | HY-123639 |
| M.Wt: | 460.95 |
| Formula: | C27H25ClN2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO;10 mM in DMSO |
LM-4108 (N-(2-Phenylethyl)-indomethacin amide) is a selective and orally active COX-2 inhibitor with an IC50 of 0.06 μM for purified human COX-2. LM-4108 shows anti-inflammatory activity and may be effective in prevention of cancer. Half-lives for the disappearance of 10 μM LM-4108 in rat, human, and mouse liver microsomes were 11 min, 21 min, and 51 min, respectively[1]. IC50 & Target:IC50: 0.06 μM (human COX-2)[1]
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