Clamikalant (sodium)
CAS No. : 261717-22-0
(Synonyms: HMR 1098)
| Size | Price | Stock |
|---|---|---|
| 5mg | $110 | In-stock |
| 10mg | $215 | In-stock |
| 25mg | $430 | In-stock |
| 50mg | $690 | In-stock |
| 100mg | $1100 | In-stock |
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| Cat. No. : | HY-15208 |
| M.Wt: | 493.96 |
| Formula: | C19H21ClN3NaO5S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 50 mg/mL (ultrasonic) |
Clamikalant sodium (HMR 1098) is an ATP-sensitive potassium (KATP) channel blocker. Clamikalant sodium can be used for the research of arrhythmia[1].
In Vitro: Clamikalant sodium (HMR 1098; 40 μM) prevents improvement effect of Levosimendam on left ventricular developed pressure (LVDP) recovery rate, abolishes the inhibitory effect of Levosimendan on hypothermic preservation-induced activation of calpain, cleavage of Bid, and apoptosis[2].
Clamikalant sodium (HMR 1098; 30 µM, 24 hours) reduces cellular viability, increases the apoptosis of Neonatal rat cardiomyocytes (NRCs) [3].
Clamikalant sodium (30 µM) decreases the Bcl-2 protein level and increases the Bax protein level in the LPS-exposed NRCs[3].
In Vivo: Clamikalant sodium (HMR 1098; 6.0 mg/kg; 5 min prior to EET administration) completely abolishes the cardioprotection produced by epoxyeicosatrienoic acid (EET)[1].
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