Naproxen (sodium)
CAS No. : 26159-34-2
| Size | Price | Stock |
|---|---|---|
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| 25g | $29 | In-stock |
| 100g | $65 | In-stock |
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| Cat. No. : | HY-15030A |
| M.Wt: | 252.24 |
| Formula: | C14H13NaO3 |
| Purity: | >98 % |
| Solubility: | H2O : 75 mg/mL (ultrasonic;warming);DMSO : 5 mg/mL (ultrasonic) |
Naproxen sodium is a COX-1 and COX-2 inhibitor with IC50s of 8.72 and 5.15 μM, respectively in cell assay. IC50 & Target: IC50: 8.72 μM (COX-1), 5.15 μM (COX-2)[1] In Vitro: Naproxen etemesil is a lipophilic, non-acidic, inactive prodrug of naproxen that is hydrolysed to pharmacologically active Naproxen once absorbed. Naproxen is a well known nonsteroidal anti-inflammatory drug. Naproxen is approximately equipotent inhibitor of COX-1 and COX-2 in intact cells with IC50s of 2.2 μg/mL and 1.3 μg/mL, respectively[1]. In Vivo: Naproxen exerts an anti-inflammatory and antifibrotic effect in mouse model of bleomycin-induced lung fibrosis. Naproxen also downregulates TGF-β levels and Smad3/4 complex formation[2]. Naproxen is shown to inhibit the time-courses of pain, fever and PGE2 with similar potencies (IC50=27, 40, 13 μM)[3].
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