Direct Blue 1
CAS No. : 2610-05-1
(Synonyms: Chicago Sky Blue 6B)
| Size | Price | Stock |
|---|---|---|
| 500mg | $50 | In-stock |
| 1 g | Get quote | |
| 5 g | Get quote | |
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| Cat. No. : | HY-D0939 |
| M.Wt: | 992.80 |
| Formula: | C34H24N6Na4O16S4 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic);H2O : 2.08 mg/mL (ultrasonic) |
Direct Blue 1 (Chicago Sky Blue 6B) is a complex dye for background autofluorescence in immunofluorescence histochemistry. Direct Blue 1 is a potent and competitive VGLUT inhibitor. Direct Blue 1 can inhibit the Aβ-binding small molecule PrP ligand. Direct Blue 1 has anti-inflammatory activity[1][2][3][4][5][6].
In Vitro:Direct Blue 1 (0.1, 1, 10 μM, 9 days) can bind α-synuclein and inhibit its aggregation, thus blocking the proliferation of α-synuclein between SH-SY5Y cells[4].
Direct Blue 1 (5, 10, 20 μM, 48 h) inhibits RANKL-induced osteoclasts and bone resorption in vitro by inhibiting NF-κB signaling and promoting proteasome-mediated MIF degradation[5].
In Vivo:Direct Blue 1 (2 or 8 mg/kg, subcutaneously, for 4 weeks) alleviates inflammatory bone destruction and osteoporosis induced by titanium particles in mice[5].
Direct Blue 1 (7.5 μg, intraventricular injection) alleviates methamphetamine-induced hyperactivity and behavioral sensitization in mice[6].
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