PD173955
CAS No. : 260415-63-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $50 | In-stock |
| 5mg | $100 | In-stock |
| 10mg | $180 | In-stock |
| 25mg | $370 | In-stock |
| 50mg | $555 | In-stock |
| 100mg | $832 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-10395 |
| M.Wt: | 443.35 |
| Formula: | C21H16Cl2N4OS |
| Purity: | >98 % |
| Solubility: | DMSO : 10 mg/mL (ultrasonic;warming;heat to 80°C) |
PD173955 is an orally active inhibitor of Src (IC50= 22 nM), Yes, Abl, ATP and MAP kinases. PD173955 can effectively prevent the mitotic process and has anticancer activity[1][2][3][4].
IC50 & Target:IC50: 22 nM (Src)[1].
In Vitro:PD173955 inhibits cell growth in MDA-MB-468 and MCF-7 breast cancer cells with IC50 values of 500 nM and 1 μM, respectively[1].
PD173955 (100 nM; 10 min) significantly inhibits the activity of src and yes kinases in MDA-MB-468 breast cancer cells[1].
PD173955 (5 μM; 24 h) can block the cells in the G2-M phase and has anti-mitotic activity in MDA-MB-468 breast cancer cells[1].
PD166326 (0.1-1000 nM; 42 h) can inhibit cell proliferation in R10(-) cells with IC50 0.2 nM, and can inhibit stem cell factor (SCF) -dependent proliferation in parental MO7e cells with IC50 12 nM[4].
In Vivo:PD166326 (50 mg/kg; Oral gavage; Twice daily) has anti-leukemia activity in CML mice[4].
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