Fmoc-NH-PEG1-CH2COOH
CAS No. : 260367-12-2
| Size | Price | Stock |
|---|---|---|
| 1g | $39 | In-stock |
| 5g | $133 | In-stock |
| 10g | $265 | In-stock |
| 25g | $411 | In-stock |
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| Cat. No. : | HY-W055861 |
| M.Wt: | 341.36 |
| Formula: | C19H19NO5 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Fmoc-NH-PEG1-CH2COOH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Fmoc-NH-PEG1-CH2COOH is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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